The first chamber of RenehaVis™ contains: 2.2% of HA of an average molecular weight of 1 million Daltons. The second chamber of RenehaVis™ contains: 1.0% of HA of an average molecular weight of 2 million Daltons.
All viscosupplementation try to help knee OA patients regain a healthy physiological state of the knee. Low molecular weight HA is known to be able to act as a lubricant in the knee whereas high molecular HA is known for its ability to absorb shocks experienced by the knee. Low molecular weight HA has 2 other functions: -Diffuse through the cartilage to protect the chondrocytes (note: a cell which help create endogenous HA and proteoglycans) which are commonly destroyed in knee OA patients. This is often terms as the CAGING EFFECT. - Diffuse to the synoviocytes at the synovial membrane to activate them. This results in the generation of endogenous HA. This action is known as the MECHANOSENSITIVE EFFECT. This is why RenehaVis™ has a concentration of low molecular weight HA – to achieve these 3 criteria needed in an OA knee. The high molecular weight HA is at a lower concentration as it only has 1 function (shock absorber) and it only has to maintain this function whilst the low molecular weight HA acts.